In December 2014, the FDA approved the world's first bispecific antibody, blinatumomab (Blincyto), for the treatment of acute lymphocytic leukemia (ALL). Since then, more than 120 bispecific antibody molecules have entered the clinical pipeline.
With the opening of the double-antibiotic market, global biotechnology companies have invested heavily in the development of bispecific antibody drugs, hoping to open new routes to cancer treatment "New World." As a product of genetic engineering, bispecific antibodies allow one antibody-like molecule to bind multiple different antigens at once. For example, Amgen's blinatumomab, whose molecule is formed by the joining of two single-chain variable regions (scFv) of an antibody, one of which targets the T cell activation molecule CD3 and the other targets B. Cellular antigen CD19.
Before detailing the innovations of foreign companies in bispecific antibodies, the author first listed a list of "innovative companies" in the domestic layout of bispecific antibody drugs, to let you know about the situation in China.
Wuhan Youzhiyou Bio-Pharmaceutical Co., Ltd. (New Third Board listed)
Related core technology: double antibody chimeric technology
Related products: Tumor therapeutic diabody (YBODY)
R & D product line:
Jiannenglong Pharmaceutical Technology (Shanghai) Co., Ltd.
Related Core Technology: Immune Antibody Technology Platform (ITabTM)
Related products: Tumor therapeutic diabody (YBODY)
R & D product line:
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