Commonly used animal experiments have three anesthesia methods: isoflurane gas anesthesia, ether anesthesia and traditional injection anesthesia. Now, isoflurane gas anesthesia has been widely used as the main animal anesthesia method in medical research. What is the difference and advantage of isoflurane gas anesthesia compared with ether anesthesia and traditional injection anesthesia?
1. ether anesthesia
Ether anesthesia can be said to be an ancient inhalation anesthetic method. As an anesthetic, it has the advantage that it is anesthesia fast, and the animal wakes up quickly after surgery, but it has more obvious disadvantages.
1) Ether is not suitable for induction of anesthesia, especially in mice, where the concentration is too long and the time is too long, the animal is extremely vulnerable to death;
2) Ether has a strong pungent odor, which will strongly stimulate the respiratory tract, promote the increase of mucus secretion, and thus the risk of clogging the respiratory tract. In the early stage of anesthesia, excitement is often strengthened. Therefore, it is necessary to have any care and assistance at any time during anesthesia. Anesthetic drugs, otherwise the animals are also prone to death;
3) Ether can not be changed or controlled at any time during use, so it is only suitable for short-term experiments, such as blood removal from the eyeball, blood sampling from the femoral artery, and injection in the tail vein;
4) Ether is an organic substance. It is flammable, explosive and inconvenient to use. Therefore, its use has been gradually reduced and gradually eliminated.
2. Traditional injection anesthesia
Traditional drug injection anesthetics commonly include ketamine, sodium pentobarbital, chloral hydrate, urethane, atropine and the like.
1) These anesthetics are usually anesthetized for too long, like sodium pentobarbital anesthesia, generally lasting 4-6 hours, and often our animal operation time is only about half an hour, so the animal is not easy to wake up, improve the animal's mortality rate;
2) Injecting anesthesia with these drugs has severe respiratory and cardiovascular inhibition effects, has a short apnea effect, and requires strict dose control, and often due to individual differences in animals, the dose is not easy to grasp, and it is easy to cause accidents;
3) Drug injection anesthesia is easy to cause complications, it will disturb the normal metabolism of animals, bring great side effects, and it is easy to produce false positive test results. The results are gradually not recognized internationally. In order to reduce the experimental anesthetic effect and risk, it often takes several An injection of anesthetic can be used at the same time to avoid this.
3. Isoflurane gas anesthesia
Isoflurane is a colorless and transparent liquid, which is a general anesthetic. It is inhaled into the blood vessels through the respiratory tract of animals, reaches the brain through the blood circulation, and inhibits the central nervous system. It can achieve both analgesic and unconscious effects.
1) The animal enters the anesthesia state faster and wakes up quickly. Once the anesthesia is stopped, the animal can wake up within 2 minutes.
2) The depth of anesthesia is easy to control. If the animal is found to be in poor condition during the operation, the anesthesia can be stopped immediately or the oxygen can be quickly rescued, so the safety is very good;
3) The morbidity and mortality of animals are low, and the success rate of animal surgery is high;
4) Inhaled anesthetic does not participate in metabolism in the body, and is almost completely discharged from the alveoli by breathing, which has no effect on the experimental results. The experimental repeatability is good, and the research results are easily recognized internationally.
In summary, it is not difficult to see the advantages and benefits of isoflurane gas anesthesia and the reasons for being widely used in medicine. Ruiwode life science and technology professional isoflurane manufacturer, with authoritative SGS certification, 15 years of industry experience, products are exported to more than 80 countries and regions, quality is guaranteed!
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