Experts believe that cancer testing will be as simple as blood glucose testing and pregnancy testing in a few years. Recently, Ohio State University chemists showed a test strip costing only 50 cents in the Journal of American Chemical Society for the detection of diseases such as cancer and malaria, and only one drop of blood for test samples. .
As convenient as a pregnancy test: a drop of blood, a test strip, can detect cancer and malaria
In rural Africa and Southeast Asia, thousands of people die from malaria, and hundreds of millions of people are infected every year. Dr. Abraham Badu-Tawiah of the Ohio State University tried to provide a cheap malaria diagnosis method for these areas, and led the team to conduct the study. However, during the research, Dr. Badu-Tawiah found that the method can also be used to detect other antibody-producing methods. Diseases, including ovarian and colorectal cancers.
According to the researchers, after the blood sample is dropped into the test strip, it is sent to the laboratory for routine testing. This means that people only need to consult a doctor if they have a positive result. The technique can be used for those who cannot visit the doctor regularly. People provide simple disease diagnosis measures.
This technique uses wax ink to track the channel and reservoir profile on the test strip, which penetrates the paper to form a water barrier to capture the blood sample and secure it between the layers. Papers of 8.5-11 feet can hold dozens of tests, and each test is divided into strips that are larger than the stamp. Dr. Badu-Tawiah said, “In the process of testing, people only need to drop the blood into the test strip and post it to the testing laboratory. The test strip looks like a pregnancy test kit, but the test method is not same."
Pregnancy tests the paper by dissolving the surface with enzymes or gold nanoparticles. The test strips in this study contain synthetic chemical probes that carry positive charges. These ion probes can be ultra-sensitively detected by hand-held mass spectrometers. . Dr. Badu-Tawiah said, “The enzyme is very picky, it must be stored at the right temperature and cannot be stored in dry or exposed light; but the ion probe is very powerful, it is not affected by light, temperature and humidity, even in Africa. It can't help it. So you just need to mail the test strip to the hospital and make sure it is still valid when you arrive at the hospital."
The researchers said they have used the test strip to successfully detect the most common protein biomarkers for malaria parasites and Plasmodium falciparum, and have successfully detected ovarian cancer protein markers - cancer antigen 125 and markers in colorectal cancer and other cancers. Carcinoembryonic antigen. In addition, the researchers also observed the fading of the detection signal from time to time. It was found that the intensity of the detection signal did not change within one month, which means that the detection method is stable and the detection period is one month. Researchers believe that people in remote areas no longer have to worry about the failure of test strips in the mailing process, which means that the health care of rural populations in remote areas has entered a new era.
However, researchers believe that developed areas like the United States can also benefit from the study because they can be tested at home, eliminating the need to see a doctor. In the United States, such test strips may be particularly useful for people with a family history of cancer, or for those who have received cancer treatment. With this test strip, patients may not have to go to the hospital regularly for regular check-ups, and they can self-test more frequently at home.
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