Cockayne Syndrome is a kind of "premature aging" in a broad sense. Patients will age 5-10 times faster than normal people. The survival time is generally no more than 20 years old. The incidence rate is two or three million. First, there is currently no effective treatment in clinical practice.
In mid-2016, at the Peking University Third Hospital, a 14-year-old girl with Cocaine syndrome received a stem cell treatment, and the doctor tried to reverse her rapidly aging body with no precedent. The mesenchymal stem cells transplanted by the patient are from the placenta of the patient's newborn healthy younger brother.
In April, at an academic forum in Shenzhen, Xu Xiaoyu, founder of Boya Stem Cell Company, called it “the first attempt to reverse aging in the worldâ€. He said that in this treatment, Boya stem cells cooperated with Peking University Third Hospital to provide the necessary technology, equipment and therapeutic use of placental mesenchymal stem cells. Xu Xiaotong did not disclose the specific treatment costs, but said that it was "astronomical figures", but it was not borne by the patient's family.
Xu Xiaotong and Peking University Third Hospital have said that patients receiving stem cell treatment have significantly improved in many physiological indicators. "This is the first in the world in terms of a clear reversal of aging in the human body," he told the author. In terms of ethics, Xu Xiaotong said that the third hospital of Peking University has been recognized by the Chinese Ethics Society, and the treatment has also been recognized ethically.
In addition, Xu Xiaotong also said that the treatment case "will be published in an influential scientific journal", but has not yet been submitted, because "more material and arguments are needed because I hope to write it as an influential one." article".
However, relevant scholars said that because the details of the treatment data have not been announced, they remain on the sidelines in terms of safety and effectiveness.
In a previous news report, Dean Qiao Jie and his team who operated the clinical treatment at Peking University Third Hospital revealed that they would undergo four stem cell transplants to compare blood assessments with other detectable indicators. After observation, the next treatment plan will be developed.
Xu Xiaolan revealed that in January 2017, the patient's first treatment has been completed, the follow-up treatment plan is still under study, and the project has not yet been completed.
The author contacted Peking University Third Hospital to try to understand the latest progress of the clinical treatment. Relevant personnel said that they are currently in the observation stage, and the relevant treatment team is too busy to be interviewed.
What is Cocaine syndrome?
Cocaine syndrome is a rare disease of recessive inheritance. If both father and mother carry the disease-causing gene, 25% of the children they give birth may be sick, 25% may not carry the disease-causing gene, 50% It may become a carrier of the causative gene but not onset.
According to the introduction of Cocaine's syndrome on the National Library of Medicine website, Cocaine's syndrome can be divided into three types depending on the severity and time of onset. According to statistics, one in every 2 million to 3 million newborns in the United States and Europe has Cocaine syndrome.
The pathogenesis of Cocaine syndrome is now clear, mainly caused by mutations in the ERCC6 and ERCC8 loci on the chromosome. ERCC6 and ERCC8 are genes encoding DNA repair-related proteins that play an important role in the repair of DNA damage. DNA can be damaged by ultraviolet light, toxic chemicals, radiation, etc., but the human body can generally repair itself. Patients with Cocaine syndrome are unable to complete normal self-repair, leading to cell death and accelerated aging.
Patients with Cocayne syndrome. Beijing Satellite TV screenshot
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