Drug toxicity
The median lethal dose for commercial use in mice is as follows (g/kg): 26 (flooding agent), 28 (decoction), 46.5 (prescription), all oral; 1.05 (flooding agent), 1.3 (decoction ), 5.3 (elixants), all intraperitoneal injections. Wild radishes are red and white. According to the lethal response to mice, the toxicity of red is about 1 times greater than that of white, and the toxicity of both red and white is significantly reduced after boiling for 2 hours. Rabbit oral dry radish powder (5-10g/kg), in addition to reduced activity, no other obvious symptoms of poisoning. Cat oral 2.5-10g/kg, all vomiting, the greater the dose, the more severe vomiting reaction, 10g/kg group still vomiting on the second day, this group of four cats died within 2 days. Dogs were given 1 g/kg orally, and vomiting occurred. There was no other reaction except for less activity. Rats took oral decoction 5g/kg daily for 3 weeks without any obvious abnormalities. The toxic component of Phytolacca sinensis, acidic steroidal saponin, was administered to mice by intraperitoneal injection with a median lethal dose of 0.065 mg/g. Phytolacca aquaticus had a median lethal dose of 26 g/kg, a half lethal dose of 28 g/kg, and a lethal dose of 46.5 g/kg. The mice were injected with a half lethal dose of water in the abdominal cavity. 1.05g/kg, the half-lethal dose of decoction was 1.3g/kg, and the half lethal dose of lixiviant was 5.3g/kg. Different animal species have different susceptibility to P. schizonepis. Cats and dogs are more sensitive and susceptible to poisoning, followed by rabbits. It has been reported that because of thrombocytopenia, there are often bleeding gums and epistaxis, and taking commercial decoction (Prussian land 15g, red dates 10), and unconsciousness and polyuria. After serving fresh commercial roots (15g) for 2 hours, nausea, vomiting, severe water diarrhea, dizziness, unclear language, restlessness, muscle twitching, cyanosis, bilateral pupils, etc Water shock and tachycardia, ventricular premature beats and other symptoms of poisoning. The Phytolacca extract had no significant effect on the general activities, food intake, body weight, liver function, renal function, and hemogram of the rats. It had no significant damage to the liver function of normal rats and rabbits, nor did it exacerbate the toxicity of CCl4 in animals. Liver damage, but the extract can act directly on the heart, it is not suitable for intravenous administration. The toxic components in Phytolacca are not yet known, but the commercial land can be detoxicated by repeated boiling or steaming for a long time. If it is fried together with pork, the dosage should reach 250g without discomfort. It shows that the toxic components are unstable to heat.
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