Recently, a research report published in the international magazine Circulation Research, researchers from the University of Minnesota and other institutions through research developed a revolutionary 3D bioprinting patch that can help repair patients after a heart attack In the presence of scarred heart tissue, this study is critical for the treatment of tissue damage in patients with heart attack.
According to the American Heart Association, heart disease is the number one killer of American deaths, causing more than 360,000 deaths per year; during a heart attack, blood flow from the patient's body is often not pumped into the heart muscle. It causes heart cell death; our body cannot replace these cardiomyocytes, so scar tissue is formed in the heart of the body, which puts the patient at risk of impaired heart function and future heart failure.
In this study, researchers used laser-based 3D bioprinting technology to incorporate stem cells derived from adult heart cells into a special scaffold that can grow on a special scaffold and in a laboratory culture dish. Synchronous beating can also be achieved. When the cell patch was placed in the body of a mouse model that mimicked a heart attack, the researchers found that the heart function of the mouse body increased significantly over the next four weeks, because the patch was a native structure in the heart. The protein and cellular components, which are transformed into a part of the heart and absorbed by the body, free the patient from surgery.
Researcher Brenda Ogle said that this is a huge breakthrough in the treatment of heart disease, and in the future we should probably expand to repair the heart of large animals, such as humans. This research differs from previous research in that researchers can develop such patches based on digital three-dimensional structural proteins of the original heart tissue, which can create the natural physical structure of the heart through 3D printing technology, and may be expected in the future. Heart cell types derived from stem cells are integrated, and using only 3D printing technology, researchers can achieve a micron resolution to mimic the structure of the original heart tissue.
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