A new mathematical model developed by the UAlberta research team reveals the progression of HIV infection in the brain, and clinicians and researchers are developing nasal sprays for more effective drug treatment.
PhD student Weston Roda and the team of mathematics and statistics science professor Michael Lee's model development used data from patients who died 5 to 15 years after infection, as well as known HIV-building biological processes to predict AIDS from the time of infection. The pattern of viral development and progression in the brain. It is the first model of infectious disease in the brain.
Since the development of antiretroviral therapy in the 1990s, HIV infection in the brain has been an unknown point for scientists.
"The nature of HIV makes it possible to cross the blood-brain barrier that infects macrophages or white blood cells within two weeks of infection. Antiretroviral drugs, the treatment of HIV cannot easily enter the brain," Rhoda said.
This produces a so-called virus reservoir where the virus in the body can sleep and where the drug is relatively inaccessible. Prior to this study, scientists could only study brain infections during autopsy. The new model allows scientists to go back and understand the progress and development of HIV infection in the brain. Using this information, researchers can determine the extent to which antiretroviral therapy in the brain is needed to reduce active infections.
"The more we understand and can treat viral reservoirs, the closer we are to developing an overall suppression strategy for HIV infection," Rhoda said. In fact, his work has been used in the University of Alberta laboratory.
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