Professor Huang Zhili and associate professor Yang Surong of the School of Basic Medical Sciences at Fudan University used a highly automated sleep awakening analysis system to reveal the secrets of sleep regulation. The study provides new ideas and potential therapeutic targets for clinical treatment of insomnia with neurological dysfunction and improvement of sleep disorders of affective disorders. Recently, "PLOS Biology" published this important achievement online.
Huang Zhili said that neuropsychiatric disorders are often accompanied by severe sleep disturbances, which is closely related to the dysfunction of dopaminergic neurons in the brain. Finding the regulation mechanism of dopamine activity in the brain (discovering the mystery of sleep regulation) has always been an urgent scientific problem to be solved.
The above study found that the newly identified brain stem structure composed of gamma-aminobutyric acid neurons, "Rhesus mediate nucleus" (RMTg), has extensive fiber projections to midbrain dopaminergic neurons, where the neurons Physiological sleep promotion, and participated in the regulation of sleep homeostasis.
The research team used a highly automated sleep arousal analysis system and used chemical genetics to activate the rat's "inner nucleus-covered nucleus" neurons and found that the total amount of sleep in the animals increased significantly and the depth of sleep increased. Conversely, if damaged, "the inside of the kiss was affected. Capping the nucleus or inhibiting its activity will reduce the amount of sleep and depth of sleep in animals. The animals whose "inner nucleus of the kiss was destroyed" will have a shallow depth of sleep as they sleep during the forced awakening period. This confirms that "the inner nucleus of the kiss" is an important basis for the regulation of sleep homeostasis.
Further studies have shown that if the activity of the "inner nucleus of the kiss" is increased, gamma-aminobutyric acid is released and the activity of dopaminergic neurons in the midbrain is inhibited, thereby promoting sleep (in animals, gamma-aminobutyric acid is almost exclusively present in nerves. In tissues, it is an important inhibitory neurotransmitter that participates in a variety of metabolic activities and has high physiological activity. If the activity of the "medial nucleus of the kiss" decreases, the dopaminergic neurons in the midbrain lose their inhibitory activity. Increase, which induces awakening.
The study confirmed that "the inner nucleus of the kiss" is an indispensable nuclei for initiation and maintenance of sleep and an important "braking" for the dopamine system in the brain. (Reporter Sun Guogen's correspondent Xu Weihong)
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