Western medicine application
1. The osmium contained in Polygonatum is similar to that of lily of the valley. Yuzhu glycosides have a strong heart effect on isolated frog hearts. The effect of Yuzhu decoction is similar to that of Yuzhu glycosides.
2. Intraperitoneal injection of Polygonatum odoratum can enhance the phagocytosis of peritoneal macrophages in burned mice, increase the serum hemolysin antibody level, and improve the proliferative response of splenic lymphocytes to ConA.
3, Yuzhu sweet and fatty, soft and moist, is a good medicine to blindly raise Yin and Sheng Jin. Vitamin A contained in odoratum improves chapped and rough skin conditions, making it soft and lubricated. Play a role in skin care.
4. The product has the ability to promote antibody production in experimental animals, increase macrophage phagocytosis percentage and phagocytosis index, promote interferon synthesis, inhibit the growth of Mycobacterium tuberculosis, reduce blood sugar, lower blood fat, relieve atherosclerotic plaque formation, make peripheral blood vessels and Coronary dilation, prolonged anti-anoxia time, strong heart, anti-oxidation, anti-aging effects. There are similar corticosteroid-like effects.
Effect on the heart
A small dose of eucalyptus decoction and tincture can rapidly increase the pulsatile heart beat in isolated frogs, while high doses weaken or even stop the heartbeat. Reports have suggested that the effect of Yuzhu on the heart is related to the lingering kuehri and lily of the valley. Experiments showed that: Yuzhu injection (100%) had no effect on small doses of isolated frog hearts, while large doses showed inhibitory effects; contraction forces on isolated rabbit hearts were first inhibited and then excited and had no effect on heart rate; There was no significant effect on the contractility and heart rate of rabbit ventricular recumbent heart; it had a protective effect on acute myocardial ischemia induced by pituitrin in rabbits.
Effect on blood pressure
When rabbits were intravenously injected with 20% yew bamboo decoction 1～5ml, the blood pressure increased slowly. Small-dose Yuzhu decoction has no effect on blood pressure in anesthetized dogs, and its blood pressure can be temporarily decreased at higher doses.
It has also been reported that the bamboo stem and leaf infusion, decoction, etc. (variety is not specified) have a temporary antihypertensive effect on rabbits and dogs. After severing the vagus nerve on both sides and atropine injection, the antihypertensive effect is weakened.
Effect on blood sugar
5. Intramuscular injection of rabbits with 0.5g/kg Polygonatum soaks can increase blood glucose. Oral osmanthus extract, the blood glucose rises first and then falls, has a significant inhibitory effect on epinephrine-induced hyperglycemia, and also inhibits glucose and alloxan-induced hyperglycemia in rats.
Effect on blood vessels
The experimental results of vascular perfusion of the whole body blood vessels and lower extremities of the frog showed that 20% of Yuzhu (produced in Shandong Lushan) decoction can significantly reduce the vascular perfusion. Anesthetized dogs can intravenously inject 20% of Yuzhu decoction into 10 ml to reduce the kidney volume. Other reports indicate that 100% Polygonatum (eastern Yuquan) Injection has a dilatation effect on the blood vessels of the lower limbs. The experiment of vascular perfusion of isolated rabbit ear showed that 100% Yuzhu injection 0.4ml/kg was injected into the infusion tube to expand blood vessels. In contrast, the isolated rabbit ear veins with nerve connections were kept injecting 0.4 ml/kg into the contralateral ear vein. No significant expansion was observed, indicating that the effect of the expansion of blood vessels on the osmanthus was not related to nerves.
Effects on Blood Lipid and Experimental Atherosclerotic Plaque
The pharmacological teaching and research group of Jinzhou Medical College reported that 100% Yuzhu decoction was given to experimental hyperlipidemia rabbits every 5 ml, 3 times a day for 30 days, compared with the control group at 10, 20 after administration. Triglycerides, blood cholesterol, and B-lipoprotein all decreased in the 30 days. Yuzhu (Northeast Yuquan) injection or intramuscular injection 2 times a day, a total of 4 Morgan. The results showed that Polygonatum had a role in preventing the elevation of triglycerides, and blood cholesterol was significantly increased after administration than before administration. Therefore, it is believed that Yuzhu injection has a certain therapeutic effect on hypertriglyceridemia. The animal atherosclerotic plaque formation (visual observation) has a certain degree of mitigation.
Effect on immune function of burned mice
Gastrointestinal ethanol extract can significantly increase the level of mouse serum hemolysin antibody, enhance the phagocytic function of peritoneal macrophages, and improve the proliferative response of splenic lymphocytes to ConA, indicating that Polygonatum may be a kind of body fluid Immune and phagocytosis-based immunostimulants.
Effect on Serum Colony Stimulating Factor in Mice
The activities of colony stimulating factor (CSF) in the conditioned medium (CM) were compared using the (3)H-TdR incorporation method and the classical and agar colony culture method, and the results were significantly correlated. Polygonatum odoratum extract 140, 280, 560, 1120, 2240 mg/kg mice were injected intraperitoneally once or five times with serum 6 hours per well, 40 μl per well (final concentration 20%), resulting in serum CSF levels following a single injection. The amount of bamboo increased and peaked at 560 mg/kg, then decreased with increasing injection volume. The five injections of serum CSF levels almost became a horizontal line, and the dose-effect relationship was not significant. The serum after one injection was at 56°C. After warming in the water bath for 30 minutes, the CSF level was significantly higher than that of the non-heated serum, and the trend was similar, reaching a peak at 560 mg/kg, and then gradually decreasing as the amount of Yuzhu increased. Dynamic changes of serum CSF after intraperitoneal injection of 140mg/kg of Polygonatum: intraperitoneal injection of Rhizoma Polygonatum 140mg/kg, serum 1, 3, 6, 12, 24, 48 hours, 40μl per well, results 1 hour after Rhizoma Polygonati The middle CSF rapidly rises, drops rapidly after peaking at 6 hours, and approaches normal levels at 24 hours. There is a clear dose-effect relationship. Inducing CSF also induces colony-suppressing factor (CIF). They participate in the body's immunity and hematopoiesis. adjust.
Effect on smooth muscle
20% Polygonatum odoratum decoction can inhibit the excitability of isolated intestine in mice. Only extemporaneous stimulatory effects on isolated uteri in mice.
Other effects
With Yuzhu decoction for frog body and lower limb perfusion, can make blood vessels shrink. Phyllostachys pubescens injection (100%) has a dilatation effect on the blood vessels of the lower extremities of the quail; it also expands the vascular perfusion of the isolated rabbit ear, but its vasodilator effect has nothing to do with the nerves.
Decoction of odoratum slightly stimulated isolated uterus in mice, and its intestinal activity increased first, then gradually decreased and the peristalsis weakened.
Polygonatum decoction gavage, the experimental hyperlipidemia in rabbits, triglycerides, cholesterol and β-lipoprotein have reduced effect. Injection of Yuzhu injection by intragastric administration or intramuscular injection has the effect of preventing triglyceride elevation, but cholesterol is significantly increased after administration than before administration; it has a certain mitigation effect on the formation of atherosclerotic plaque in animals.
If 2.5% of eucalyptus is added to the feed, the mortality of mice infected with H37RV human Mycobacterium tuberculosis can be reduced, but the lesions are only slightly reduced, but the increase in concentration is not effective.
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