There are new solutions to the causes of high incidence of cancer in diabetic population
August 27, 2015 Source: Xinhuanet
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];Recently, the international authoritative scientific journal "Nature·Communication" published the research results of the team of Professor Hu Zhuowei, the national key laboratory of natural drug active substances and functions of the Institute of Materia Medica, Chinese Academy of Medical Sciences. The stress-inducing protein TRIB3 can link diabetes-related metabolic risks like a bond. Factors and tumor progression. This discovery provides a new perspective for human understanding of tumor development and provides new targets and drug candidates for the treatment of diabetes-related tumors.
Previous studies on the relationship between diabetes and tumors at home and abroad suggest that insulin or insulin-like growth factor 1 (IGF-1) is involved in tumorigenesis and development. However, the academic community is controversial because of the inability to obtain satisfactory anti-tumor effects by simply blocking insulin and IGF-1 receptors.
Hu Zhuowei said that a major breakthrough in the study was the discovery of a class of stress-inducing proteins called TRIB3, a series of metabolic abnormalities commonly found in diabetic patients, including hyperglycemia, hyperinsulinemia, high IGF-1, and local hypoxia. Both can alter the expression of this protein. The increased expression of TRIB3 leads to a worse prognosis in tumor patients, and inhibition of TRIB3 expression can inhibit tumor growth and metastasis.
This study further illustrates the mechanism by which TRIB3 causes tumorigenesis. Hu Zhuowei said that the two major degradation systems in cells, the autophagy system and the ubiquitinated proteasome system, are used to maintain the metabolism of the cells themselves and the renewal of certain organelles. The study found that highly expressed TRIB3 competitively interacts with the autophagy-associated receptor SQSTM1, resulting in the accumulation of various tumor-promoting factors in cells, producing a large amount of reactive oxygen species, promoting tumorigenesis and development. In this way, blocking the binding of TRIB3 and SQSTM1 restores the cell's ability to self-degrade.
Hu Zhuowei said that along this line of thought, the team screened a class of lead compound alpha-helical peptide A2 that binds to TRIB3, which removes the interaction between TRIB3 and SQSTM1 and shows both at the cell and animal levels. Strongly inhibit the role of tumor growth and metastasis.
Omega-3 fatty acid is a long-chain, polyunsaturated fatty acid found in plants and marine organisms. Studies have shown that saturated fatty acids have adverse effects on health, while omega-3 fatty acids, as polyunsaturated fatty acids, have many health benefits. Different types of evidence suggest that the decrease of omega-3 fatty acid concentration can cause mood disorders. Some preliminary research results suggest that it can effectively treat a variety of mental disorders, such as bipolar disorder, schizophrenia and dementia. For pregnant and lactating women, it is a safe and effective treatment.
There are eight sources of omega-3: Antarctic krill, seals (seals), deep-sea fish, purple perilla seed, flaxseed, qiyazi (qiyazi), seaweed, South American oil vine and yak.
Fish / fish oil: it should be noted that only deep-sea fish are rich in omega-3. Unlike other three plant products, fish contain cholesterol. People with diabetes, hypertension and other diseases should consult a doctor before consuming fish oil to supplement omega3. In addition, fish is a common allergen, which will cause allergic reactions in many people, including children. If you are prone to allergic constitution before eating, please consult your doctor. Deep sea fish oil is rich in unsaturated fatty acids such as EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid), which can significantly reduce cholesterol and soften blood vessels. Ruan Guangfeng, an expert of China food and nutrition information exchange center, said that EPA and DHA are the main components of fish oil that play a role in health care for the human body. They come from fish fat. The quality of fish oil is marked by the content of EPA and DHA.
Seaweed: the deep-sea rhynchophyta contains Omega-3. Some deep-sea fish ingest omega-3 because they prey on these algae. Because the existing methods of cultivating and extracting seaweed oil do great harm to the environment, it still needs some time to improve and improve in order to realize commercial production.
Omega 3 Fish Oil, Rosemary Essential Oil, Lavender Essential Oil, Peppermint Essential Oil
Xi'an Tian Guangyuan Biotech Co., Ltd. , https://www.tgybiotech.com