A medical paper recently published by the British journal Nature News introduces a millimeter-scale miniature eye patch that delivers drugs to the eye to treat diseases. The device has been tested in mice and is expected to enable patients to treat eye diseases at home in the future.
Several diseases that threaten vision, such as glaucoma and age-related macular degeneration, often make doctors feel very tricky. On the one hand, because these diseases are more serious, such as glaucoma, which is one of the three major blind diseases that cause blindness in humans, and macular degeneration as a natural consequence of the deterioration of old age is the main cause of blindness in people over 50 years old; This is because many drugs are the safest and most effective when treating this type of disease, but injections may cause problems such as discomfort, infection and serious eye damage. Eye drops may be washed away and usually inefficient. .
This time, Chen Peng, a researcher at Nanyang Technological University in Singapore, and colleagues developed a millimeter-sized eye patch containing microneedle arrays that deliver the drug to the eyeball in a controlled manner. The microneedles will gradually dissolve and slowly release the drug into the surrounding environment.
In the mouse experiment, the researchers applied a slight pressure on the thumb to attach the eye to the surface of the mouse eye. The researchers used corneal neovascularization as a model, demonstrating that after a single treatment with the monoclonal antibody DC101 delivered by the eye patch, the neovascular area of ​​the mouse was reduced by about 90%. In contrast, even with higher doses of eye drops, significant therapeutic effects are not achieved.
Researchers say that in the future, clinical research is needed to assess the effectiveness and safety of this new device for humans. (Reporter Zhang Mengran)
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