Researchers at the Salk Institute in the United States have found that two microRNAs help tumor cells escape anti-tumor immunity and accelerate their spread.
The study, published September 18 in Nature Cell Biology, may point the way to cancer treatment in the future.
Juan of the Salk Institute for Biological Research? Carlos? Ispiusua? Professor Juan Carlos Izpisua Belmonte said, "When tumor cells are produced, immune stress will also appear to inhibit the spread of tumor cells. However, by blocking the anti-tumor immune response, cancer cells can escape anti-tumor immunity. â€
Tumor cells differentiate very rapidly, so they can almost exhaust all the blood around them, which creates a hypoxic environment, which we call hypoxia. Under hypoxic conditions, human cells destroy themselves, but the microenvironment surrounding hypoxic tumor tissue sometimes protects tumor cells.
Ispiusua? Professor Belmont said: "Our research points out how cancer cells react in a changing microenvironment and suppress anti-tumor immunity through inherent biosignals."
In the experiment, the researchers provided different levels of microRNAs to different tumor cells, and found that the levels of miR25 and miR93 microRNAs increased under hypoxic conditions.
In the experiment, the researchers reduced the levels of miR25 and miR93 in tumor cells of 148 cancer patients, and found that high levels of tumor cells caused a much worse condition than the low levels. This is exactly the opposite of cGAS molecules. The lower the level of cGAS molecules in tumor cells, the more severe the patient's condition will be.
"Based on this result, we hypothesized that the two microRNAs, miR25 and miR93, cause a decrease in cGAS levels, thereby creating an anti-immune environment for tumor cells," said a research assistant at the Salk Gene Expression Laboratory. ."
Source: World Wide Web
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